Association between IL2RA and juvenile idiopathic arthritis (JIA) disease severity at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study (CAPS)
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چکیده
منابع مشابه
Association between IL2RA and juvenile idiopathic arthritis (JIA) disease severity at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study (CAPS)
Results 185 children with JIA (median age 7.2 years(IQR 3.6, 11.7), 65% female) were included. Median CHAQ score at presentation was 0.75(IQR 0.13, 1.38). There was a trend towards higher disability with increased number of copies of the rare allele of rs2104286 (Table 1) (OR 8.00 (0.93, 68.79), p = 0.06). An association was also seen between increased disability and homozygosity for the rare a...
متن کاملAssociation between duration of symptoms and severity of disease at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study
OBJECTIVES To study the association between disease severity at first presentation to paediatric rheumatology (PRh) and length of time since symptom onset in children recruited to the Childhood Arthritis Prospective Study. METHODS Children or=2 weeks were recruited from five UK hospitals. Data including demographics, disease features, Childho...
متن کاملDisease activity and disability in children with juvenile idiopathic arthritis one year following presentation to paediatric rheumatology. Results from the Childhood Arthritis Prospective Study
OBJECTIVE Inflammatory arthritis in childhood is variable in terms of both presentation and outcome. This analysis describes disease activity in children with juvenile idiopathic arthritis (JIA) during the first year following presentation to a paediatric rheumatologist and identifies predictors of moderate to severe disability [defined using a Childhood HAQ (CHAQ) score >or=0.75] at 1 year. ...
متن کاملTreatment prescribing patterns in patients with juvenile idiopathic arthritis (JIA): Analysis from the UK Childhood Arthritis Prospective Study (CAPS)☆☆★
OBJECTIVE Initial treatment of juvenile idiopathic arthritis (JIA) is largely based on the extent of joint involvement, disease severity and ILAR category. The licensing of biologic therapies for JIA has expanded treatment options. The aims of the study are (1) to describe treatment prescribing patterns in JIA over the first 3 years following first presentation to paediatric rheumatology and (2...
متن کاملPredictors of disability in children with inflammatory arthritis, two and three years after first presentation to paediatric rheumatology. Results from the childhood arthritis prospective study (CAPS)
Background Inflammatory arthritis (IA) in children is a chronic and often disabling disease with variable outcome. Up to 1/3 of children are reported to have active disease progressing into adulthood. The Childhood Arthritis Prospective Study (CAPS) is a prospective longitudinal inception cohort study which aim is to identify genetic and environmental predictors of shortand long-term outcome of...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2008
ISSN: 1546-0096
DOI: 10.1186/1546-0096-6-s1-p14